Season combinatorial intervention predictions with Salt & Peper

arXiv:2404.16907v1 Announce Type: cross
Abstract: Interventions play a pivotal role in the study of complex biological systems. In drug discovery, genetic interventions (such as CRISPR base editing) have become central to both identifying potential therapeutic targets and understanding a drug's mechanism of action. With the advancement of CRISPR and the proliferation of genome-scale analyses such as transcriptomics, a new challenge is to navigate the vast combinatorial space of concurrent genetic interventions. Addressing this, our work concentrates on estimating the effects …

abstract advancement arxiv become crispr cs.lg discovery drug discovery editing pivotal predictions q-bio.cb q-bio.gn role study systems targets type understanding