Single-sample image-fusion upsampling of fluorescence lifetime images

arXiv:2404.13102v1 Announce Type: cross
Abstract: Fluorescence lifetime imaging microscopy (FLIM) provides detailed information about molecular interactions and biological processes. A major bottleneck for FLIM is image resolution at high acquisition speeds, due to the engineering and signal-processing limitations of time-resolved imaging technology. Here we present single-sample image-fusion upsampling (SiSIFUS), a data-fusion approach to computational FLIM super-resolution that combines measurements from a low-resolution time-resolved detector (that measures photon arrival time) and a high-resolution camera (that measures intensity only). To solve this …

abstract acquisition arxiv cs.cv data data-fusion eess.iv engineering fusion image images imaging information interactions limitations major microscopy physics.bio-ph physics.optics processes processing resolution sample signal signal-processing technology type