VADA: a Data-Driven Simulator for Nanopore Sequencing

arXiv:2404.08722v1 Announce Type: cross
Abstract: Nanopore sequencing offers the ability for real-time analysis of long DNA sequences at a low cost, enabling new applications such as early detection of cancer. Due to the complex nature of nanopore measurements and the high cost of obtaining ground truth datasets, there is a need for nanopore simulators. Existing simulators rely on handcrafted rules and parameters and do not learn an internal representation that would allow for analysing underlying biological factors of interest. Instead, …

abstract analysis applications arxiv cancer cost cs.lg data data-driven datasets detection dna enabling low nature q-bio.qm real-time sequencing simulator truth type