AbDiffuser: Full-Atom Generation of In-Vitro Functioning Antibodies. (arXiv:2308.05027v1 [q-bio.BM])

We introduce AbDiffuser, an equivariant and physics-informed diffusion model
for the joint generation of antibody 3D structures and sequences. AbDiffuser is
built on top of a new representation of protein structure, relies on a novel
architecture for aligned proteins, and utilizes strong diffusion priors to
improve the denoising process. Our approach improves protein diffusion by
taking advantage of domain knowledge and physics-based constraints; handles
sequence-length changes; and reduces memory complexity by an order of magnitude
enabling backbone and side chain …

architecture arxiv bio denoising diffusion diffusion model novel physics physics-informed process protein proteins protein structure representation