AlphaFold Distillation for Improved Inverse Protein Folding. (arXiv:2210.03488v1 [q-bio.BM])

Inverse protein folding, i.e., designing sequences that fold into a given
three-dimensional structure, is one of the fundamental design challenges in
bio-engineering and drug discovery. Traditionally, inverse folding mainly
involves learning from sequences that have an experimentally resolved
structure. However, the known structures cover only a tiny space of the protein
sequences, imposing limitations on the model learning. Recently proposed
forward folding models, e.g., AlphaFold, offer unprecedented opportunity for
accurate estimation of the structure given a protein sequence. Naturally,
incorporating …

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