Web: http://arxiv.org/abs/2206.11255

June 24, 2022, 1:10 a.m. | Yiming Fang, Xuejun Liu, Hui Liu

cs.LG updates on arXiv.org arxiv.org

It has been verified that only a small fraction of the neoantigens presented
by MHC class I molecules on the cell surface can elicit T cells. The limitation
can be attributed to the binding specificity of T cell receptor (TCR) to
peptide-MHC complex (pMHC). Computational prediction of T cell binding to
neoantigens is an challenging and unresolved task. In this paper, we propose an
attentive-mask contrastive learning model, ATMTCR, for inferring TCR-antigen
binding specificity. For each input TCR sequence, we …

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