Data Augmentation Scheme for Raman Spectra with Highly Correlated Annotations

In biotechnology Raman Spectroscopy is rapidly gaining popularity as a process analytical technology (PAT) that measures cell densities, substrate- and product concentrations. As it records vibrational modes of molecules it provides that information non-invasively in a single spectrum. Typically, partial least squares (PLS) is the model of choice to infer information about variables of interest from the spectra. However, biological processes are known for their complexity where convolutional neural networks (CNN) present a powerful alternative. They can handle non-Gaussian noise …

annotations augmentation biotechnology cs.lg data information least molecules process product q-bio.qm records spectroscopy spectrum squares technology