Web: http://arxiv.org/abs/2205.03261

May 9, 2022, 1:11 a.m. | Tanja Hernández Rodríguez, Anton Sekulic, Markus Lange-Hegermann, Björn Frahm

cs.LG updates on arXiv.org arxiv.org

Development and optimization of biopharmaceutical production processes with
cell cultures is cost- and time-consuming and often performed rather
empirically. Efficient optimization of multiple-objectives like process time,
viable cell density, number of operating steps & cultivation scales, required
medium, amount of product as well as product quality depicts a promising
approach. This contribution presents a workflow which couples uncertainty-based
upstream simulation and Bayes optimization using Gaussian processes. Its
application is demonstrated in a simulation case study for a relevant
industrial task …

arxiv design optimization processes

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