[Discussion] Is this an example of data leakage?

I’m working on a research project using machine learning to try to discover patterns in gene promoters. I’m concerned about data leakage in our model, but I want some outside opinions before I push too hard with my lab to change our methodology. Perhaps someone in this community can help me understand this issue better.

Our machine learning model is an L1-regularized logistic regression model that uses sequence patterns as features to predict a binary outcome for a transcription start …

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