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DiskCache
Simon Willison's Weblog simonwillison.net
Grant Jenks built DiskCache as an alternative caching backend for Django (also usable without Django), using a SQLite database on disk. The performance numbers are impressive - it even beats memcached in microbenchmarks, due to avoiding the need to access the network.
The source code (particularly in core.py) is a great case-study in SQLite performance optimization, after five years of iteration on making it all run as fast as possible.
backend caching case code core database django five grant network numbers optimization performance python sqlite study