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Evaluation of large language models for discovery of gene set function
April 2, 2024, 7:53 p.m. | Mengzhou Hu, Sahar Alkhairy, Ingoo Lee, Rudolf T. Pillich, Dylan Fong, Kevin Smith, Robin Bachelder, Trey Ideker, Dexter Pratt
cs.CL updates on arXiv.org arxiv.org
Abstract: Gene set analysis is a mainstay of functional genomics, but it relies on curated databases of gene functions that are incomplete. Here we evaluate five Large Language Models (LLMs) for their ability to discover the common biological functions represented by a gene set, substantiated by supporting rationale, citations and a confidence assessment. Benchmarking against canonical gene sets from the Gene Ontology, GPT-4 confidently recovered the curated name or a more general concept (73% of cases), …
abstract analysis arxiv cs.ai cs.cl databases discovery evaluation five function functional functions gene genomics language language models large language large language models llms q-bio.gn q-bio.mn set type
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