EvolutionaryScale Introduces ESM3: A Frontier Multimodal Generative Language Model that Reasons Over the Sequence, Structure, and Function of Proteins

Researchers from Evolutionary Scale PBC, Arc Institute, and the University of California have developed ESM3, an advanced generative language model for proteins. ESM3 can simulate evolutionary processes to create functional proteins vastly different from known ones. It integrates sequence, structure, and function to generate proteins following complex prompts. Notably, ESM3 generated a new fluorescent protein, esmGFP, which is 58% different from any known fluorescent proteins—a degree of difference comparable to 500 million years of natural evolution. This breakthrough demonstrates ESM3’s …

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