FDNet: Frequency Domain Denoising Network For Cell Segmentation in Astrocytes Derived From Induced Pluripotent Stem Cells

Artificially generated induced pluripotent stem cells (iPSCs) from somatic cells play an important role for disease modeling and drug screening of neurodegenerative diseases. Astrocytes differentiated from iPSCs are important targets to investigate neuronal metabolism. The astrocyte differentiation progress can be monitored through the variations of morphology observed from microscopy images at different differentiation stages, then determined by molecular biology techniques upon maturation. However, the astrocytes usually ``perfectly'' blend into the background and some of them are covered by interference information …

cells cs.cv cs.lg denoising differentiation disease diseases domain generated modeling network progress role screening segmentation stem targets through