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HelixFold-Single: MSA-free Protein Structure Prediction by Using Protein Language Model as an Alternative. (arXiv:2207.13921v1 [q-bio.BM])
cs.LG updates on arXiv.org arxiv.org
AI-based protein structure prediction pipelines, such as AlphaFold2, have
achieved near-experimental accuracy. These advanced pipelines mainly rely on
Multiple Sequence Alignments (MSAs) and templates as inputs to learn the
co-evolution information from the homologous sequences. Nonetheless, searching
MSAs and templates from protein databases is time-consuming, usually taking
dozens of minutes. Consequently, we attempt to explore the limits of fast
protein structure prediction by using only primary sequences of proteins.
HelixFold-Single is proposed to combine a large-scale protein language model
with …
arxiv bio free language language model prediction protein protein structure protein structure prediction