Image segmentation of treated and untreated tumor spheroids by Fully Convolutional Networks

arXiv:2405.01105v1 Announce Type: new
Abstract: Multicellular tumor spheroids (MCTS) are advanced cell culture systems for assessing the impact of combinatorial radio(chemo)therapy. They exhibit therapeutically relevant in-vivo-like characteristics from 3D cell-cell and cell-matrix interactions to radial pathophysiological gradients related to proliferative activity and nutrient/oxygen supply, altering cellular radioresponse. State-of-the-art assays quantify long-term curative endpoints based on collected brightfield image time series from large treated spheroid populations per irradiation dose and treatment arm. Here, spheroid control probabilities are documented analogous to in-vivo …

abstract advanced art arxiv cellular convolutional cs.cv culture image impact interactions matrix networks q-bio.qm q-bio.to radio segmentation state systems therapy type