Web: http://arxiv.org/abs/2110.04624

Jan. 31, 2022, 2:11 a.m. | Wengong Jin, Jeremy Wohlwend, Regina Barzilay, Tommi Jaakkola

cs.LG updates on arXiv.org arxiv.org

Antibodies are versatile proteins that bind to pathogens like viruses and
stimulate the adaptive immune system. The specificity of antibody binding is
determined by complementarity-determining regions (CDRs) at the tips of these
Y-shaped proteins. In this paper, we propose a generative model to
automatically design the CDRs of antibodies with enhanced binding specificity
or neutralization capabilities. Previous generative approaches formulate
protein design as a structure-conditioned sequence generation task, assuming
the desired 3D structure is given a priori. In contrast, we …

arxiv bio design graph network neural neural network

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