Leak Proof CMap; a framework for training and evaluation of cell line agnostic L1000 similarity methods

arXiv:2404.18960v1 Announce Type: cross
Abstract: The Connectivity Map (CMap) is a large publicly available database of cellular transcriptomic responses to chemical and genetic perturbations built using a standardized acquisition protocol known as the L1000 technique. Databases such as CMap provide an exciting opportunity to enrich drug discovery efforts, providing a 'known' phenotypic landscape to explore and enabling the development of state of the art techniques for enhanced information extraction and better informed decisions. Whilst multiple methods for measuring phenotypic similarity …

abstract acquisition arxiv cellular connectivity cs.lg database databases evaluation framework leak line map protocol q-bio.qm responses training type