Multi-level protein pre-training with Vabs-Net

In recent years, there has been a surge in the development of 3D structure-based pre-trained protein models, representing a significant advancement over pre-trained protein language models in various downstream tasks. However, most existing structure-based pre-trained models primarily focus on the residue level, i.e., alpha carbon atoms, while ignoring other atoms like side chain atoms. We argue that modeling proteins at both residue and atom levels is important since the side chain atoms can also be crucial for numerous downstream tasks, …

advancement alpha carbon cs.ai cs.lg development focus language language models pre-trained models pre-training protein q-bio.bm tasks training