ODBO: Bayesian Optimization with Search Space Prescreening for Directed Protein Evolution. (arXiv:2205.09548v1 [q-bio.BM])

Directed evolution is a versatile technique in protein engineering that
mimics the process of natural selection by iteratively alternating between
mutagenesis and screening in order to search for sequences that optimize a
given property of interest, such as catalytic activity and binding affinity to
a specified target. However, the space of possible proteins is too large to
search exhaustively in the laboratory, and functional proteins are scarce in
the vast sequence space. Machine learning (ML) approaches can accelerate
directed evolution …

arxiv bayesian bio evolution optimization protein search space