Pathology Steered Stratification Network for Subtype Identification in Alzheimer's Disease. (arXiv:2210.05880v1 [q-bio.QM])

Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative
disorder characterized by beta-amyloid, pathologic tau, and neurodegeneration.
The massive heterogeneity between neurobiological examinations and clinical
assessment is the current biggest challenge in the early diagnosis of
Alzheimer's disease, urging for a comprehensive stratification of the aging
population that is defined by reliable neurobiological biomarkers and closely
associated with clinical outcomes. However, existing statistical inference
approaches in neuroimaging studies of AD subtype identification fail to take
into account the neuropathological domain knowledge, …

alzheimer's arxiv bio disease identification network