PhagoStat a scalable and interpretable end to end framework for efficient quantification of cell phagocytosis in neurodegenerative disease studies

arXiv:2304.13764v2 Announce Type: replace-cross
Abstract: Quantifying the phagocytosis of dynamic, unstained cells is essential for evaluating neurodegenerative diseases. However, measuring rapid cell interactions and distinguishing cells from background make this task very challenging when processing time-lapse phase-contrast video microscopy. In this study, we introduce an end-to-end, scalable, and versatile real-time framework for quantifying and analyzing phagocytic activity. Our proposed pipeline is able to process large data-sets and includes a data quality verification module to counteract perturbations such as microscope movements …

abstract arxiv cells contrast cs.cv cs.lg disease diseases dynamic eess.iv framework however interactions measuring microscopy neurodegenerative disease processing quantification scalable studies type video