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Predicting O-GlcNAcylation Sites in Mammalian Proteins with Transformers and RNNs Trained with a New Loss Function
Feb. 28, 2024, 5:41 a.m. | Pedro Seber
cs.LG updates on arXiv.org arxiv.org
Abstract: Glycosylation, a protein modification, has multiple essential functional and structural roles. O-GlcNAcylation, a subtype of glycosylation, has the potential to be an important target for therapeutics, but methods to reliably predict O-GlcNAcylation sites had not been available until 2023; a 2021 review correctly noted that published models were insufficient and failed to generalize. Moreover, many are no longer usable. In 2023, a considerably better RNN model with an F$_1$ score of 36.17% and an MCC …
abstract arxiv cs.lg function functional loss multiple protein proteins q-bio.mn roles therapeutics transformers type
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