PRIME: Uncovering Circadian Oscillation Patterns and Associations with AD in Untimed Genome-wide Gene Expression across Multiple Brain Regions. (arXiv:2208.12811v1 [q-bio.GN])

The disruption of circadian rhythm is a cardinal symptom for Alzheimer's
disease (AD) patients. The full circadian rhythm orchestration of gene
expression in the human brain and its inherent associations with AD remain
largely unknown. We present a novel comprehensive approach, PRIME, to detect
and analyze rhythmic oscillation patterns in untimed high-dimensional gene
expression data across multiple datasets. To demonstrate the utility of PRIME,
firstly, we validate it by a time course expression dataset from mouse liver as
a cross-species …

arxiv bio brain gene genome patterns prime