Quoting D. Richard Hipp, 18 years ago

The default prefix used to be "sqlite_". But then Mcafee started using SQLite in their anti-virus product and it started putting files with the "sqlite" name in the c:/temp folder. This annoyed many windows users. Those users would then do a Google search for "sqlite", find the telephone numbers of the developers and call to wake them up at night and complain. For this reason, the default name prefix is changed to be "sqlite" spelled backwards.

— D. Richard Hipp, …

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