Three-Dimensional Amyloid-Beta PET Synthesis from Structural MRI with Conditional Generative Adversarial Networks

arXiv:2405.02109v1 Announce Type: cross
Abstract: Motivation: Alzheimer's Disease hallmarks include amyloid-beta deposits and brain atrophy, detectable via PET and MRI scans, respectively. PET is expensive, invasive and exposes patients to ionizing radiation. MRI is cheaper, non-invasive, and free from ionizing radiation but limited to measuring brain atrophy.
Goal: To develop an 3D image translation model that synthesizes amyloid-beta PET images from T1-weighted MRI, exploiting the known relationship between amyloid-beta and brain atrophy.
Approach: The model was trained on 616 PET/MRI …

abstract adversarial alzheimer's arxiv beta brain cs.cv disease eess.iv free generative generative adversarial networks measuring motivation mri networks patients pet scans synthesis three-dimensional type via