Amortized Inference for Heterogeneous Reconstruction in Cryo-EM. (arXiv:2210.07387v1 [cs.CV])

Cryo-electron microscopy (cryo-EM) is an imaging modality that provides
unique insights into the dynamics of proteins and other building blocks of
life. The algorithmic challenge of jointly estimating the poses, 3D structure,
and conformational heterogeneity of a biomolecule from millions of noisy and
randomly oriented 2D projections in a computationally efficient manner,
however, remains unsolved. Our method, cryoFIRE, performs ab initio
heterogeneous reconstruction with unknown poses in an amortized framework,
thereby avoiding the computationally expensive step of pose search while …

arxiv cryo-em inference