Heterogeneous reconstruction of deformable atomic models in Cryo-EM. (arXiv:2209.15121v1 [q-bio.BM])

Cryogenic electron microscopy (cryo-EM) provides a unique opportunity to
study the structural heterogeneity of biomolecules. Being able to explain this
heterogeneity with atomic models would help our understanding of their
functional mechanisms but the size and ruggedness of the structural space (the
space of atomic 3D cartesian coordinates) presents an immense challenge. Here,
we describe a heterogeneous reconstruction method based on an atomistic
representation whose deformation is reduced to a handful of collective motions
through normal mode analysis. Our implementation …

arxiv bio cryo-em